Paul Lingor

Clinical Neuroscience

LingorLab, Department of Neurology, University Medical Center, Georg-August-Universität Göttingen, Göttingen, Germany




"Disease-modifying therapeutic strategies for neurodegenerative disorders: From bench to bedside – can it work?"

Neurodegenerative diseases affect a growing number of people in industrialized countries with aging populations. In addition to increasing socioeconomic costs, they represent a burden on patients, relatives and care givers. Parkinson’s disease (PD) and Amyotrophic lateral sclerosis (ALS) are exemplary neurodegenerative disorders with distinct clinical features and numerous molecular similarities. In this talk I will set the work of our lab on ALS and PD in context and discuss how we analyze axonal degeneration in vitro and in vivo, identify biomarker candidates from various human sources and finally translate preclinical findings to a therapeutic trial in humans.