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Emre Yaksi

Session:
Neurobiology


Institute:
Kavli Institute for Systems Neuroscience, NTNU, Trondheim, Norway
 
Website:
www.yaksilab.com

Biography:
 
Dr. Emre Yaksi was born on March 13, 1978 in Turkey. He received his B.Sc. (2001) in Molecular Biology at Middle East Technical University, Ankara-Turkey. He obtained his PhD (2007) in the laboratory of Dr. Rainer Friedrich at Max Planck Institute for Medical Research, Heidelberg-Germany. He worked as a post-doctoral fellow (2007-2010) in Dr Rachel Wilson’s laboratory at Harvard Medical School, Boston-USA. He leads his research team at NERF since December 2010 and appointed as an assistant professor at KU Leuven since October 2011. Since January 2015, Dr Yaksi is an associate professor at Kavli Institute for Systems Neuroscience-NTNU in Trondheim.

Abstract:

Studying the function and connectivity of neural networks in zebrafish brain
 
The habenula (Hb) is a brain region with increasing popularity due to its strong link to addiction, mood disorders and experience dependent fear. We demonstrated that Hb neurons respond to odors and light asymmetrically. Moreover, we showed that Hb neurons exhibit structured spontaneous activity that is spatially and temporally organized. This spontaneous activity resembles neural attractors, which can switch the preferred state of the Hb and regulate the transmission of sensory information to downstream monoaminergic brainstem nuclei. In order to explore the source of Hb spontaneous activity, we investigate the local connectivity within Hb and the global functional inputs to Hb. Our results showed that recurrent excitatory connections within Hb is important for maintaining spatio-temporal organization of Hb activity. Moreover, we observed that functional inputs form zebrafish homologues of hippocampus (Dl) and amygdala (Dm) and sensory inputs from visual and olfactory systems are the major drivers of spontaneous Hb activity. Our results suggested that these limbic and sensory inputs are integrated in Hb in a non-linear fashion and can regulate sensory representations in Hb. We propose that Hb lies in the heart of a brain wide network and act as “a hub” or “a switchboard”, which can regulate or gate the communication of sensory systems and limbic forebrain areas with the monoaminergic brainstem nuclei that control animal behaviors.